Jim Moriarty

Revenge of the Furries. Video Link.

[Submitterated by Chocolatey Shatner.]

Cibo Matto, "Sugar Water" (1996), directed by Michel Gondry.

Pitchfork's terrific list of the top 50 music videos of the 1990s.

Predicting protein structures with a multiplayer online game

Nature 466, 756 (2010). doi:10.1038/nature09304

Authors: Seth Cooper, Firas Khatib, Adrien Treuille, Janos Barbero, Jeehyung Lee, Michael Beenen, Andrew Leaver-Fay, David Baker, Zoran Popović & Foldit players

People exert large amounts of problem-solving effort playing computer games. Simple image- and text-recognition tasks have been successfully ‘crowd-sourced’ through games, but it is not clear if more complex scientific problems can be solved with human-directed computing. Protein structure prediction is one such problem: locating the biologically relevant native conformation of a protein is a formidable computational challenge given the very large size of the search space. Here we describe Foldit, a multiplayer online game that engages non-scientists in solving hard prediction problems. Foldit players interact with protein structures using direct manipulation tools and user-friendly versions of algorithms from the Rosetta structure prediction methodology, while they compete and collaborate to optimize the computed energy. We show that top-ranked Foldit players excel at solving challenging structure refinement problems in which substantial backbone rearrangements are necessary to achieve the burial of hydrophobic residues. Players working collaboratively develop a rich assortment of new strategies and algorithms; unlike computational approaches, they explore not only the conformational space but also the space of possible search strategies. The integration of human visual problem-solving and strategy development capabilities with traditional computational algorithms through interactive multiplayer games is a powerful new approach to solving computationally-limited scientific problems.

Created by DeviantArt user Gamefan84, who says all that needs to be said: "Craziest request ever: Chewie riding a giant cute squirrel chasing down Nazis. He needs long flowing fur and a giant roar."

You might stop by his DeviantArt page and tell him how great this is.

(via BB Submitterator / The High Definite)

This is a lovely variation on The Leaning Tower illusion. I can’t believe that these two photographs are identical….

Any idea why it works?

I think the worst offender here is the History Channel and all their programs on the so-called "World War II".

Let's start with the bad guys. Battalions of stormtroopers dressed in all black, check. Secret police, check. Determination to brutally kill everyone who doesn't look like them, check. Leader with a tiny villain mustache and a tendency to go into apopleptic rage when he doesn't get his way, check. All this from a country that was ordinary, believable, and dare I say it sometimes even sympathetic in previous seasons.

I wouldn't even mind the lack of originality if they weren't so heavy-handed about it. Apparently we're supposed to believe that in the middle of the war the Germans attacked their allies the Russians, starting an unwinnable conflict on two fronts, just to show how sneaky and untrustworthy they could be? And that they diverted all their resources to use in making ever bigger and scarier death camps, even in the middle of a huge war? Real people just aren't that evil. And that's not even counting the part where as soon as the plot requires it, they instantly forget about all the racism nonsense and become best buddies with the definitely non-Aryan Japanese.

Not that the good guys are much better. Their leader, Churchill, appeared in a grand total of one episode before, where he was a bumbling general who suffered an embarrassing defeat to the Ottomans of all people in the Battle of Gallipoli. Now, all of a sudden, he's not only Prime Minister, he's not only a brilliant military commander, he's not only the greatest orator of the twentieth century who can convince the British to keep going against all odds, he's also a natural wit who is able to pull out hilarious one-liners practically on demand. I know he's supposed to be the hero, but it's not realistic unless you keep the guy at least vaguely human.